Background: Obesity represents a critical global health challenge with multifactorial etiopathogenesis, characterized by complex metabolic dysregulation. Current epidemiological data indicates a dramatic increase in obesity prevalence. The intricate relationship between dietary fibre and metabolic homeostasis presents a promising avenue for intervention and prevention strategies. Study is designed to comprehensively investigate the molecular mechanisms of dietary fibre in modulating metabolic parameters and obesity-related metabolic dysfunction through a longitudinal, systematic intervention.

Methods: A prospective, randomized controlled trial was conducted with 742 adult participants (aged 35-65) over 12 months. Participants were stratified into: Control Group (n=372): Standard dietary recommendations. Intervention Group (n=370): High-fibre dietary intervention (25-35g daily). Comprehensive assessments were performed at 3-month intervals, measuring: Anthropometric parameters (BMI, Waist Circumference), Metabolic markers (Total Cholesterol, Fasting Glucose)

Results: Statistically significant improvements were observed in the intervention group across multiple metabolic parameters: BMI reduction: Mean decrease of 3.0±0.5 (p<0.001), Waist Circumference: Mean reduction of 9.8±1.2 cm (p<0.001). Total Cholesterol: Mean decrease of 36.4±2.5 mg/dL (p<0.001), Fasting Glucose: Mean reduction of 18.0±1.7 mg/dL (p<0.001).

Conclusion: Dietary fibre represents a critical nutritional strategy with multifaceted protective mechanisms against metabolic dysfunction and obesity progression. dietary fibre positively influences metabolic homeostasis, offering a promising non-pharmacological approach to obesity management.