Author(s): Mahadevan L and Murugasan AG

Abstract:
In the present study, we have analyzed the nephro-protective and antioxidant activity of Aragwadi yogam using in vitro models. The extract of Aragwadi yogam showed safety upto 25 µg/ml and also exhibited 72.54% inhibiting of aldose reductase at high concentration of 200 µg/ml. Physico-chemical properties of Aragwadadi yogam extract revealed high extract yield (4.53%) and nearly neutral pH of 6.76 (Table 3). Water solubility of the extract is found to be high (78.58%) and also the total phenolic content is 559.68 mg GAE/100 g). Antioxidants activity of Aragwadadi yogam extract in terms of radical scavenging activity against DPPH (IC-50 537 µg/ml), superoxide (IC-50 1355 µg/ml), hydrogen peroxide (IC-50 164 µg/ml) and hydroxyl radicals (IC-50 308 µg/ml). Hence Aragwadadi yogam could be explored as natural antioxidant and nephro-protective agent.