Methodology of study: The total sample for the present study included 400 adolescents i.e 200 from deferent girls high schools and 200 from women’s colleges which are the most of HIV prevalence blocks of the Ganjam district of Odisha state. By using exploratory and the descriptive study design, the researcher attempts to describe female adolescents’ knowledge and understanding regarding HIV/AIDS, and the channels of transmission. A scheduled questionnaire was used covering all aspects of HIV/ AIDS and observation methods were also used to collect the data from the adolescent girls. To analysis data the researcher used frequency percentages and the t- tests were computed. The study revealed that majority of adolescents girls have higher 31 percents of then report the channels of transmissions though sexual intercourses and which is correct answer over all the repot of the study indicates that that knowledge about mode of HIV transmission is still poor among the adolescent girls.

Conclusion and Recomondation: The present study will help to focuses of adolescents level of knowledge to import for better life for better future because adolescents are the really dormant stat of mind regarding HIV/AIDS the need extra guide line to increase coping skills and need for adequate support system. Right knowledge right action right time can change the life of an individual as well as the society.